We hypothesize that as one of the most consequential events in evolution, primary endosymbiosis accelerates lineage divergence, a process we refer to as the endosymbiotic ratchet. Our proposal is supported by recent work on the photosynthetic amoeba, Paulinella, that underwent primary plastid endosymbiosis about 124 Mya. This amoeba model allows us to explore the early impacts of photosynthetic organelle (plastid) origin on the host lineage. The current data point to a central role for effective population size (Ne) in accelerating divergence (...) post‐endosymbiosis due to limits to dispersal and reproductive isolation that reduce Ne, leading to local adaptation. We posit that isolated populations exploit different strategies and behaviors and assort themselves in non‐overlapping niches to minimize competition during the early, rapid evolutionary phase of organelle integration. The endosymbiotic ratchet provides a general framework for interpreting post‐endosymbiosis lineage evolution that is driven by disruptive selection and demographic and population shifts. Also see the video abstract here: https://youtu.be/gYXrFM6Zz6Q. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Commentary on “Minds, Memes, and Multiples”Timothy Sprigge (bio)In his paper “Minds, Memes and Multiples” Stephen Clark discusses the problem of multiple personality, to some considerable extent in response to Stephen Braude’s recent book First Person Plural, with eloquence, subtlety and some apposite historical references. I am delighted to have been asked to make some comments on it, developing some points I made in discussion when Professor Clark read (...) his paper at a seminar in Edinburgh.Multiple personality is certainly a fascinating subject on which anyone with views about the nature of human persons does well to cast an eye. I am grateful to both Clark and Braude for having raised my awareness of it. Clearly, Clark has been persuaded by Braude of the reality of the phenomenon as something more than just a form of extreme role-playing or play acting, 1 but also agrees with him that there is an ultimate single self behind the genuine multiplicity (Clark 1969; Braude 1991). What this ultimate self is Clark seeks to explain by reference to a single “light” which illumines all the variety (extreme in the case of multiple personality), of ideas, thoughts, emotions etc. by which we are variously swayed.Let us for simplicity take the case where the putatively distinct “persons” associated with the one human organism are three. Prima facie, there are, in these cases, three distinct centers of consciousness associated with a single human organism each capable turn and turn about of being the dominant one (that which is using the first person pronoun out aloud to speak of itself and whose desires and wishes are what is most immediately expressed in behavior).There seem to be three main features of genuine and full blooded multiple personality (as described most famously—I shall assume correctly—in Morton Prince’s The Dissociation of a Personality and Thigpen and Cleckley’s The Three Faces of Eve). First, the different centers of consciousness exhibit very different personalities, so different that the individual seems in some ways even physically altered according as to which is dominant. By personality here I mean a system of character traits rather than the principle of personal identity, whatever we think that to be. The expression “multiple personality” tends rather to blur the distinction between personality in this sense and person. Someone can change quite radically in personality without ceasing to be the same person—or at least that is how we ordinarily look at it. Second, at least one of them does not “remember” the experiences and conscious behavior of at least one of the others, while one of them does. If they really are different persons, some would think that “memory” is the wrong word here. But I am using “memory” to refer to any cognitive relation sufficiently akin to that in which we stand to our own past experiences when we [End Page 31] remember them. Third, they co-exist in the sense that at least one other of the centers is often “looking on” at the contents and public manifestations of the then dominant one.Another important factor is that they have attitudes to one another, often of hostility, which seem much more like the attitudes one can have to another person than one normally does to oneself. However, important as this is, it should not be taken as part of the definition of multiple personality, since so many of these attitudes are ones many people direct at themselves, (e.g. self-hatred and self-pity). To say that these are distinct from the hatred and pity felt towards others just because they are self-directed seems rather to beg the question.It seems to me that unless the first three conditions are met, we do not have multiple personality in a full sense. I cannot consider all possible cases in which only one or two of the conditions are met but here are some examples. Suppose that the first condition is met but not the other two. Then we would have a person subjected to striking mood swings, each mood bringing with it a contrasting set of personal loves and hates, political opinions, aesthetic tastes, sporting enthusiasms, and... (shrink)

The history of education, as it has been conceived and taught in the United States (and in the West generally), has focused almost entirely on the ways in which our own educational tradition emerged, developed, and changed over the course of the centuries. Although understandable, this means that the many other ways that societies have sought to meet the same challenges have been ignored. This book seeks to redress this oversight by providing a brief yet comprehensive review of a small (...) number of other, non-Western approaches to educational thought and practice. Understanding the ways that other peoples have tried to educate their children--as well as what counted for them as "education"--may help us to think more clearly about some of our own assumptions and values. It should also help us to become more open to alternative viewpoints about important educational matters. (shrink)

What we call “the evidential argument from evil” is not one argument but a family of them, originating (perhaps) in the 1979 formulation of William Rowe. Wykstra’s early versions of skeptical theism emerged in response to Rowe’s evidential arguments. But what sufficed as a response to Rowe may not suffice against later more sophisticated versions of the problem of evil—in particular, those along the lines pioneered by Paul Draper. Our chief aim here is to make an earlier version of skeptical (...) theism more responsive to the type abductive atheology pioneered by Draper. In particular, we suggest a moderate form of skeptical theism may be able to resist Draper’s abductive atheology. (shrink)

This text provides a brief, yet comprehensive, overview of a number of non-Western approaches to educational thought and practice. The history of education, as it has been conceived and taught in the United States (and generally in the West), has focused almost entirely on the ways in which our own educational tradition emerged, developed, and changed over the course of the centuries. Although understandable, this means the many ways that other societies have sought to meet many of the same challenges (...) have been ignored. This book seeks to redress this omission. Its premise is that gaining an understanding of the ways that other peoples educate their children--as well as what counts for them as "education"--may help us to think more clearly about some of our own assumptions and values, as well as to become more open to alternative viewpoints about important educational matters. Because it is not traditionally included in the training of educators, very few have had any real exposure to non-Western educational traditions. Thus, the audience for this book is broad and diverse. Intended as a text for both preservice and in-service teachers, each chapter includes pedagogically helpful "Questions for Discussion and Reflection" and "Recommended Further Readings." The book is equally appropriate for advanced students in graduate programs as well as faculty members. New in the Second Edition: The text has been thoroughly revised to expand and clarify points, update chapters as needed, and improve the pedagogical usefulness of the text. A section on Mayan education has been added to the chapter on the Mesoamerican educational experience. One entirely new chapter "'Familiar Strangers': The Case of the Rom" has been included. (shrink)

Informative and mind-opening, this text uniquely provides a comprehensive overview of a range of non-western approaches to educational thought and practice. Its premise is that understanding the ways that other people educate their children--as well as what counts for them as "education"--may help readers to think more clearly about some of their own assumptions and values, and to become more open to alternative viewpoints about important educational matters. The approach is deliberately and profoundly pedagogical, based in the author's own teaching (...) practice. Designed to be used in pre-service and in-service teacher education courses where substantial critical discussion and debate are encouraged, the text is enhanced by Questions for Discussion and Reflection in each chapter. Updates and Features of the Fourth Edition * NEW! Chapter 2 exploring key features of the 'western educational tradition', and information about the contemporary educational systems in different countries * NEW! Chapter 10 on traditional educational thought and practice in Oceania, with special focus on the Maori in New Zealand, the Hawai'ians, and the Australian Aboriginal peoples * Updated chapter on Africa includes fuller explanation of the diversity within the indigenous African experience, as well as several contemporary cases of state education in Africa * Updated Chapter 4 is designed to help non-Muslims to understand the Muslim educational heritage and the growing issue of Islamophobia * Exploration of Chinese education now includes a special emphasis on the thought of Confucius, the role of the imperial examination system, and the impact of political and economic changes in the 20th century * Updated analysis of contemporary educational practices in Hindu and Buddhist educational thought and practice and brief discussions of Jainism and Sikhism. (shrink)

Skeptical theism is a family of responses to the evidential problem of evil. What unifies this family is two general claims. First, that even if God were to exist, we shouldn’t expect to see God’s reasons for permitting the suffering we observe. Second, the previous claim entails the failure of a variety of arguments from evil against the existence of God. In this essay, we identify three particular articulations of skeptical theism—three different ways of “filling in” those two claims—and describes (...) their role in responding to evidential arguments of evil due to William Rowe and Paul Draper. But skeptical theism has been subject to a variety of criticisms, several of which raise interesting issues and puzzles not just in philosophy of religion but other areas of philosophy as well. Consequently, we discuss some of these criticisms, partly with an eye to bringing out the connections between skeptical theism and current topics in mainstream philosophy. Finally, we conclude by situating skeptical theism within our own distinctive methodology for evaluating world views, what we call “worldview theory versioning.”. (shrink)

A persistent complaint about modal forms of the ontological argument is that the characteristic modalized existence assumptions of these arguments are simply too close to the conclusion to be of much probative value in establish­ing it. I present an abstract form of the ontological argument in which the properties imputed to the divine nature by these assumptions are replaced by any of a wide class of properties of a sort I call “actualizing.” These include basic theistic attributes such as authorship, (...) sovereignty and omniscience. The import of these arguments is to show that the metaphysical coherence of some of the most familiar conceptions of the divine nature ensures their actual realization. (shrink)

The proliferation of computers in the business realm may lead to ethical problems between individual and societal rights, and the organization's need to control costs. In an attempt to explore the causes of this potential conflict, this study examined the varying levels of sensitivity 223 respondents assigned to different types of information typically stored in computer-based human resource information systems. It was found that information most directly related to the job — pay rate, fringe benefits, educational history — was considered (...) to be the most sensitive. Participants, however, were more concerned about certain types of individuals/groups accessing these systems than about the kinds of information contained in them. Implications of these findings are discussed. (shrink)

This paper points out some of the weaknesses of the traditional account of the Homeric phrase androteta kai hében and suggests instead that the entire phrase is a relatively recent creation of the tradition on the model of an *an(b)roteta kai hében. This phrase in turn has a clear Avestan cognate hauruuatata ameretata.

Recovering the Soul explores an area of historical philosophy that few if any others have attempted by critically comparing the metaphysical doctrines of Thomas Aquinas and Baruch Spinoza on the identity of mind and body. The central premise is that the hylomorphism of Aquinas's understanding of soul and body has a surprising affinity with Spinoza's own understanding of how human beings are enabled to exist as a single entity that is both mind and body. In the process of making the (...) case that hylomorphism can apply to Spinoza's philosophy as much as Aquinas's, the book carefully exegetes the work of each philosopher and indicates how each is internally consistent within his own system of thought. The hylomorphic reading of Spinoza helps to address some interpretive challenges that his commentators have noted and struggled to harmonize with other aspects of this monist ontology. Beyond the historical and interpretive interests the book addresses, it also makes the case that hylomorphism as a metaphysical theory of human constitution best harmonizes with contemporary studies in the human genome and provides a more comprehensive starting point for the philosophy of mind than reductionism or substance dualism. (shrink)

The government purchasing market constitutes the largest business sector in the world. While marketers would benefit from a deep understanding of both sectors, how the two sectors differ in terms of ethics and strategy largely remains unknown. The purpose of this research, therefore, is to explore differences between the for-profit and not-for-profit sectors on two critical aspects of business-to-business procurement: ethics and strategy. Using survey data from a sample of 328 procurement professionals in the for-profit and not-for-profit sectors, key differences (...) are explored. Findings suggest that buyers in the for-profit sector are more likely to behave opportunistically. Conversely, the buyers’ leaders in the not-for-profit sector behave more opportunistically and are more willing to turn a blind eye to their subordinate buyers’ opportunistic behaviors. In addition, key differences in procurement strategy are unveiled suggesting that not-for-profit procurement practices have some room for improvement. Based on the findings, theoretical and managerial implications are drawn, and a future research agenda is proposed. (shrink)

This study investigated (1) whether potential future purchasing agents were predisposed to accept gratuities or whether the practice of gratuity acceptance is a manifestation of the job itself, (2) whether the existence of a code of ethics forbidding gratuity acceptance curtails the occurrence, and (3) whether disparities in ethics policies between the sales and purchasing functions affect gratuity acceptance. Hypotheses based upon the concepts of organizational concern and institutionalized ethics are developed and empirically tested. Results suggest that future purchasing agents (...) are predisposed to accept gratuities and that formal written ethics policies decrease the acceptance of gratuities. Disparities in ethics policies between the sales and purchasing functions concerning gratuities failed to affect gratuity acceptance significantly. (shrink)

An examination of verbal hallucinations and thought insertion as examples of "alienated self-consciousness.".